Ontology highlight
ABSTRACT:
SUBMITTER: Szojka Z
PROVIDER: S-EPMC7460587 | biostudies-literature | 2020 Aug
REPOSITORIES: biostudies-literature
International journal of molecular sciences 20200817 16
HIV transactivator protein (Tat) plays a pivotal role in viral replication through modulation of cellular transcription factors and transactivation of viral genomic transcription. The effect of HIV-1 Tat on reverse transcription has long been described in the literature, however, that of HIV-2 is understudied. Sequence homology between Tat proteins of HIV-1 and 2 is estimated to be less than 30%, and the main difference lies within their N-terminal region. Here, we describe Y44A-inactivating mut ...[more]