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Characterization of bovine MHC DRB3 diversity in global cattle breeds, with a focus on cattle in Myanmar.


ABSTRACT: BACKGROUND:Myanmar cattle populations predominantly consist of native cattle breeds (Pyer Sein and Shwe), characterized by their geographical location and coat color, and the Holstein-Friesian crossbreed, which is highly adapted to the harsh tropical climates of this region. Here, we analyzed the diversity and genetic structure of the BoLA-DRB3 gene, a genetic locus that has been linked to the immune response, in Myanmar cattle populations. METHODS:Blood samples (n?=?294) were taken from two native breeds (Pyer Sein, n?=?163 and Shwe Ni, n?=?69) and a cattle crossbreed (Holstein-Friesian, n?=?62) distributed across six regions of Myanmar (Bago, n?=?38; Sagaing, n?=?77; Mandalay, n?=?46; Magway, n?=?46; Kayin, n?=?43; Yangon, n?=?44). In addition, a database that included 2428 BoLA-DRB3 genotypes from European (Angus, Hereford, Holstein, Shorthorn, Overo Negro, Overo Colorado, and Jersey), Zebuine (Nellore, Brahman and Gir), Asian Native from Japan and Philippine and Latin-American Creole breeds was also included. Furthermore, the information from the IPD-MHC database was also used in the present analysis. DNA was genotyped using the sequence-based typing method. DNA electropherograms were analyzed using the Assign 400ATF software. RESULTS:We detected 71 distinct alleles, including three new variants for the BoLA-DRB3 gene. Venn analysis showed that 11 of these alleles were only detected in Myanmar native breeds and 26 were only shared with Asian native and/or Zebu groups. The number of alleles ranged from 33 in Holstein-Friesians to 58 in Pyer Seins, and the observed versus unbiased expected heterozygosity were higher than 0.84 in all the three the populations analyzed. The FST analysis showed a low level of genetic differentiation between the two Myanmar native breeds (FST?=?0.003), and between these native breeds and the Holstein-Friesians (FST?

SUBMITTER: Giovambattista G 

PROVIDER: S-EPMC7460757 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature

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Characterization of bovine MHC DRB3 diversity in global cattle breeds, with a focus on cattle in Myanmar.

Giovambattista Guillermo G   Moe Kyaw Kyaw KK   Polat Meripet M   Borjigin Liushiqi L   Hein Si Thu ST   Moe Hla Hla HH   Takeshima Shin-Nosuke SN   Aida Yoko Y  

BMC genetics 20200901 1


<h4>Background</h4>Myanmar cattle populations predominantly consist of native cattle breeds (Pyer Sein and Shwe), characterized by their geographical location and coat color, and the Holstein-Friesian crossbreed, which is highly adapted to the harsh tropical climates of this region. Here, we analyzed the diversity and genetic structure of the BoLA-DRB3 gene, a genetic locus that has been linked to the immune response, in Myanmar cattle populations.<h4>Methods</h4>Blood samples (n = 294) were tak  ...[more]

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