Prophylactic chemotherapeutic hyperthermic intraperitoneal perfusion reduces peritoneal metastasis in gastric cancer: a retrospective clinical study.

ABSTRACT: BACKGROUND:Peritoneal metastasis is the most frequent failure in gastric cancer. This study evaluated the role of prophylactic chemotherapeutic hyperthermic intraperitoneal perfusion (CHIP) in patients after D2 dissection. METHODS:Gastric cancer patients after D2 dissection were enrolled in this study. Patients received either chemotherapy (IV group) or CHIP (CHIP group). Sites of recurrence or metastasis, disease-free survival (DFS), overall survival (OS) and adverse events were evaluated. RESULTS:Twenty-two patients received CHIP treatment, and 21 patients received chemotherapy alone. The median DFS time was 24.5 and 36.5?months in the IV group and CHIP group (P?=?0.044), respectively. The median OS time was 33.1?months in the IV group and not reached in the CHIP group (P?=?0.037). We also found that CHIP could reduce the total recurrence/metastasis rate, especially that of peritoneal metastasis. In the subgroup analysis, DFS and OS were both superior in deficient mismatch repair (dMMR) patients than in proficient MMR (pMMR) patients. CONCLUSION:This hypothesis-generating study indicates that CHIP might be feasible for gastric cancer patients after D2 resection.

SUBMITTER: Zhu L 

PROVIDER: S-EPMC7461269 | biostudies-literature | 2020 Aug

REPOSITORIES: biostudies-literature