Ontology highlight
ABSTRACT:
SUBMITTER: Chrabaszczewska M
PROVIDER: S-EPMC7461555 | biostudies-literature | 2020 Aug
REPOSITORIES: biostudies-literature
Chrabąszczewska Magdalena M Sieradzan Adam K AK Rodziewicz-Motowidło Sylwia S Grubb Anders A Dobson Christopher M CM Kumita Janet R JR Kozak Maciej M
International journal of molecular sciences 20200815 16
Human cystatin C (HCC), a cysteine-protease inhibitor, exists as a folded monomer under physiological conditions but has the ability to self-assemble via domain swapping into multimeric states, including oligomers with a doughnut-like structure. The structure of the monomeric HCC has been solved by X-ray crystallography, and a covalently linked version of HCC (stab-1 HCC) is able to form stable oligomeric species containing 10-12 monomeric subunits. We have performed molecular modeling, and in c ...[more]