Ontology highlight
ABSTRACT:
SUBMITTER: Ando H
PROVIDER: S-EPMC7461560 | biostudies-literature | 2020 Aug
REPOSITORIES: biostudies-literature
Ando Hideya H Yoshimoto Satoshi S Yoshida Moemi M Shimoda Nene N Tadokoro Ryosuke R Kohda Haruka H Ishikawa Mami M Nishikata Takahito T Katayama Bunpei B Ozawa Toshiyuki T Tsuruta Daisuke D Mizutani Ken-Ichi KI Yagi Masayuki M Ichihashi Masamitsu M
International journal of molecular sciences 20200812 16
Pigmentation in the dermis is known to be caused by melanophages, defined as melanosome-laden macrophages. In this study, we show that dermal fibroblasts also have an ability to uptake melanosomes and apoptotic melanocytes. We have previously demonstrated that normal human melanocytes constantly secrete melanosome clusters from various sites of their dendrites. After adding secreted melanosome clusters collected from the culture medium of melanocytes, time-lapse imaging showed that fibroblasts a ...[more]