Unknown

Dataset Information

0

Combined Point-of-Care Nucleic Acid and Antibody Testing for SARS-CoV-2 following Emergence of D614G Spike Variant.


ABSTRACT: Rapid COVID-19 diagnosis in the hospital is essential, although this is complicated by 30%-50% of nose/throat swabs being negative by SARS-CoV-2 nucleic acid amplification testing (NAAT). Furthermore, the D614G spike mutant dominates the pandemic and it is unclear how serological tests designed to detect anti-spike antibodies perform against this variant. We assess the diagnostic accuracy of combined rapid antibody point of care (POC) and nucleic acid assays for suspected COVID-19 disease due to either wild-type or the D614G spike mutant SARS-CoV-2. The overall detection rate for COVID-19 is 79.2% (95% CI 57.8-92.9) by rapid NAAT alone. The combined point of care antibody test and rapid NAAT is not affected by D614G and results in very high sensitivity for COVID-19 diagnosis with very high specificity.

SUBMITTER: Mlcochova P 

PROVIDER: S-EPMC7462534 | biostudies-literature |

REPOSITORIES: biostudies-literature

Similar Datasets

| EMPIAR-10891 | biostudies-other
| S-EPMC7832383 | biostudies-literature
| S-EPMC7605563 | biostudies-literature
| S-EPMC8051874 | biostudies-literature
| S-EPMC7337374 | biostudies-literature
| S-EPMC7492024 | biostudies-literature
| S-EPMC8437943 | biostudies-literature
| S-EPMC8158177 | biostudies-literature
| S-EPMC7693302 | biostudies-literature
| S-EPMC8897296 | biostudies-literature