Ontology highlight
ABSTRACT:
SUBMITTER: Khan D
PROVIDER: S-EPMC7462610 | biostudies-literature | 2020 Aug
REPOSITORIES: biostudies-literature
Khan Danish D Lee Dongju D Gulten Gulcin G Aggarwal Anup A Wofford Joshua J Krieger Inna I Tripathi Ashutosh A Patrick John W JW Eckert Debra M DM Laganowsky Arthur A Sacchettini James J Lindahl Paul P Bankaitis Vytas A VA
eLife 20200811
Yeast Sfh5 is an unusual member of the Sec14-like phosphatidylinositol transfer protein (PITP) family. Whereas PITPs are defined by their abilities to transfer phosphatidylinositol between membranes in vitro, and to stimulate phosphoinositide signaling in vivo, Sfh5 does not exhibit these activities. Rather, Sfh5 is a redox-active penta-coordinate high spin Fe<sup>III</sup> hemoprotein with an unusual heme-binding arrangement that involves a co-axial tyrosine/histidine coordination strategy and ...[more]