Ontology highlight
ABSTRACT:
SUBMITTER: Valsky D
PROVIDER: S-EPMC7462612 | biostudies-literature | 2020 Aug
REPOSITORIES: biostudies-literature
eLife 20200819
Dopamine and striatal dysfunctions play a key role in the pathophysiology of Parkinson's disease (PD) and Dystonia, but our understanding of the changes in the discharge rate and pattern of striatal projection neurons (SPNs) remains limited. Here, we recorded and examined multi-unit signals from the striatum of PD and dystonic patients undergoing deep brain stimulation surgeries. Contrary to earlier human findings, we found no drastic changes in the spontaneous discharge of the well-isolated and ...[more]