Ontology highlight
ABSTRACT:
SUBMITTER: Blackburn J
PROVIDER: S-EPMC7462630 | biostudies-literature | 2012 May
REPOSITORIES: biostudies-literature
Blackburn James J Ohazama Atsushi A Kawasaki Katsushige K Otsuka-Tanaka Yoko Y Liu Bigang B Honda Kenya K Rountree Ryan B RB Hu Yinling Y Kawasaki Maiko M Birchmeier Walter W Schmidt-Ullrich Ruth R Kinoshita Akira A Schutte Brian C BC Hammond Nigel L NL Dixon Michael J MJ Sharpe Paul T PT
Developmental biology 20120214 1
Thickening and the subsequent invagination of the epithelium are an important initial step in ectodermal organ development. Ikkα has been shown to play a critical role in controlling epithelial growth, since Ikkα mutant mice show protrusions (evaginations) of incisor tooth, whisker and hair follicle epithelium rather than invagination. We show here that mutation of the Interferon regulatory factor (Irf) family, Irf6 also results in evagination of incisor epithelium. In common with Ikkα mutants, ...[more]