Ontology highlight
ABSTRACT:
SUBMITTER: Messchendorp AL
PROVIDER: S-EPMC7462725 | biostudies-literature | 2020 Aug
REPOSITORIES: biostudies-literature
Messchendorp A Lianne AL Casteleijn Niek F NF Meijer Esther E Gansevoort Ron T RT
Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association 20200801 8
Autosomal dominant polycystic kidney disease (ADPKD) is characterized by progressive cyst formation, leading to growth in kidney volume and renal function decline. Although therapies have emerged, there is still an important unmet need for slowing the rate of disease progression in ADPKD. High intracellular levels of adenosine 3',5'-cyclic monophosphate (cAMP) are involved in cell proliferation and fluid secretion, resulting in cyst formation. Somatostatin (SST), a hormone that is involved in ma ...[more]