Ontology highlight
ABSTRACT:
SUBMITTER: Belfetmi A
PROVIDER: S-EPMC7462832 | biostudies-literature | 2020 Oct
REPOSITORIES: biostudies-literature
Belfetmi Anissa A Léger-Abraham Mélissa M
Biomolecular NMR assignments 20200609 2
Most of the translational control of gene expression in higher eukaryotes occurs during the initiation step of protein synthesis. While this process is well characterized in mammalian cells, it is less defined in parasites, including the ones that cause human Leishmaniasis. The Leishmania cap-binding isoform 1 (LeishIF4E-1) is the only isoform that binds the specific trypanosomatids-specific hypermethylated 5' cap, called cap-4, in the human stage of the parasite life cycle. We report here the e ...[more]