Ontology highlight
ABSTRACT:
SUBMITTER: Mu T
PROVIDER: S-EPMC7462855 | biostudies-literature | 2020 Sep
REPOSITORIES: biostudies-literature
Mu Tong T Wei Bingcheng B Zhu Dapeng D Yu Biao B
Nature communications 20200901 1
Pentacyclic triterpenoids (PTs) constitute one of the biggest families of natural products, many with higher oxidation state at the D/E rings possess a wide spectrum of biological activties but are poorly accessible. Here we report a site-selective C-H hydroxylation at the D/E rings of PTs paving a way toward these important natural products. We find that Schönecker and Baran's Cu-mediated aerobic oxidation can be applied and become site-selective on PT skeletons, as being effected unexpectedly ...[more]