Preservation of the Foveal Avascular Zone in Achromatopsia Despite the Absence of a Fully Formed Pit.

ABSTRACT:

Purpose

To examine the foveal avascular zone (FAZ) in patients with congenital achromatopsia (ACHM).

Methods

Forty-two patients with genetically confirmed ACHM were imaged either with Optovue's AngioVue system or Zeiss's Plex Elite 9000, and the presence or absence of a FAZ was determined. For images where a FAZ was present and could be confidently segmented, FAZ area, circularity index, and roundness were measured and compared with previously published normative values. Structural optical coherence tomography images were acquired to assess the degree of foveal hypoplasia (number and thickness of inner retinal layers present at the fovea).

Results

A FAZ was present in 31 of 42 patients imaged (74%), although no determination could be made for 11 patients due to poor i

SUBMITTER: Linderman RE 

PROVIDER: S-EPMC7463179 | biostudies-literature | 2020 Aug

REPOSITORIES: biostudies-literature