An Experimental Model of Neurodegenerative Disease Based on Porcine Hemagglutinating Encephalomyelitis Virus-Related Lysosomal Abnormalities.
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ABSTRACT:
SUBMITTER: Lan Y
PROVIDER: S-EPMC7463228 | biostudies-literature | 2020 Dec
REPOSITORIES: biostudies-literature
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An Experimental Model of Neurodegenerative Disease Based on Porcine Hemagglutinating Encephalomyelitis Virus-Related Lysosomal Abnormalities.
Lan Yungang Y Li Zi Z Wang Zhenzhen Z Wang Xinran X Wang Gaili G Zhang Jing J Hu Shiyu S Zhao Kui K Xu Baofeng B Gao Feng F He Wenqi W
Molecular neurobiology 20200902 12
Lysosomes are involved in pathogenesis of a variety of neurodegenerative diseases and play a large role in neurodegenerative disorders caused by virus infection. However, whether virus-infected cells or animals can be used as experimental models of neurodegeneration in humans based on virus-related lysosomal dysfunction remain unclear. Porcine hemagglutinating encephalomyelitis virus displays neurotropism in mice, and neural cells are its targets for viral progression. PHEV infection was confirm ...[more]
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