Dataset Information

Pattern-Reversal Visual Evoked Potentials Tests in Persons with Type 2 Diabetes Mellitus with and without Diabetic Retinopathy.

ABSTRACT: Background:Currently, diabetic retinopathy (DR) has a wide recognition as a neurovascular rather than a microvascular diabetic complication with an increasing need for enhanced detection approaches. Pattern-reversal visual evoked potentials (PRVEPs) test, as an objective electrophysiological measure of the optic nerve and retinal function, can be of great value in the detection of diabetic retinal changes. Objectives:The use of two sizes of checkerboard PRVEPs testing to detect any neurological changes in persons with type 2 diabetes mellitus (T2DM) with and without a clinically detected DR. Also, to compare the results according to the candidate age, duration, and glycemic status of T2DM. Methods:This study included 50 candidates as group A with T2DM and did not have a clinically detected DR and 50 candidates as group B with T2DM and had a clinically detected early DR and 50 candidates as controls who were neither diabetic nor had any other medical or ophthalmic condition that might affect PRVEPs test results. The PRVEPs were recorded in the consultant unit of ophthalmology in Almawani Teaching Hospital. Monocular PRVEPs testing of both eyes was done by using large (60?min) and small (15?min) checks to measure N75 latency and P100 latency and amplitude. Results:There was a statistically significant P100 latency delay and P100 amplitude reduction in both groups A and B in comparison with the controls. The difference between groups A and B was also significant. In both test results of groups A and B, the proportions of abnormal P100 latency were higher than those of P100 amplitude with a higher abnormal proportions in 15?min test. Conclusions:The PRVEP test detected neurological changes, mainly as conductive alterations affecting mostly the foveal region prior to any overt DR clinical changes, and these alterations were heightened by the presence of DR clinical changes.

SUBMITTER: Al-Najjar RS

PROVIDER: S-EPMC7463399 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature

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Pattern-Reversal Visual Evoked Potentials Tests in Persons with Type 2 Diabetes Mellitus with and without Diabetic Retinopathy.

Al-Najjar Raghda S RS Al-Aubody Nehaya M NM Al-Asadi Salah Z SZ Alabbood Majid M

Neurology research international 20200824

<h4>Background</h4>Currently, diabetic retinopathy (DR) has a wide recognition as a neurovascular rather than a microvascular diabetic complication with an increasing need for enhanced detection approaches. Pattern-reversal visual evoked potentials (PRVEPs) test, as an objective electrophysiological measure of the optic nerve and retinal function, can be of great value in the detection of diabetic retinal changes.<h4>Objectives</h4>The use of two sizes of checkerboard PRVEPs testing to detect an ...[more]

PMID: 32908701

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Project description:To systemically explore the range of visual angles that affect visual acuity, and to establish the relationship between the P1 component (peak latency ~100 ms) of the pattern-reversal visual-evoked potential (PRVEP) and the visual acuity at particular visual angles.Two hundred and ten volunteers were divided into seven groups, according to visual acuity as assessed by the standard logarithmic visual acuity chart (SLD-ii). For each group, the PRVEP components were elicited in response to visual angle presentations at 8°, 4°, 2°, 1°/60', 30', 15', and 7.5', in the whiteblack chess-board reversal mode with a contrast level of 100% at a frequency of 2 Hz. Visual stimuli were presented monocularly, and 200 presentations were averaged for each block of trials. The early and stable component P1 was recorded at the mid-line of the occipital region (oz) and analyzed with SPSS 13.00.(1) oz had the maximum P1 amplitude; there was no significant difference between genders or for interocular comparison in normal controls and subjects with optic myopia. (2) The P1 latency decreased slowly below 30', then increased rapidly. The P1 amplitude initially increased with check size, and was maximal at ~1° and ~30'. (3) The P1 latency in the group with visual acuity ≤0.2 was significantly different at 8°, 15' and 7.5', while the amplitude differed at all visual angles, compared with the group with normal vision. Differences in P1 for the groups with 0.5 and 0.6 acuity were only present at visual angles <1°. (4) Regression analysis showed that the P1 latency and amplitude were associated with visual acuity over the full range of visual angles. There was a moderate correlation at visual angles <30'. Regression equations were calculated for the P1 components and visual acuity, based on visual angle.(1) Visual angle should be taken into consideration when exploring the function of the visual pathway, especially visual acuity. A visual angle ~60' might be appropriate when using PRVEP components to evaluate poor vision and to identify malingerers. (2) increased P1 amplitude and decreased P1 latency were associated with increasing visual acuity, and the P1 components displayed a linear correlation with visual acuity, especially in the range of optimal visual angles. Visual acuity can be deduced from P1 based on visual angle.

Dataset Information

Pattern-Reversal Visual Evoked Potentials Tests in Persons with Type 2 Diabetes Mellitus with and without Diabetic Retinopathy.

Publications

Pattern-Reversal Visual Evoked Potentials Tests in Persons with Type 2 Diabetes Mellitus with and without Diabetic Retinopathy.

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