Ontology highlight
ABSTRACT:
SUBMITTER: Wagner M
PROVIDER: S-EPMC7463542 | biostudies-literature | 2020 Jul
REPOSITORIES: biostudies-literature
Wagner Michael M Doverfjord Johan G JG Tillner Joachim J Antoni Gunnar G Haack Torsten T Bossart Martin M Laitinen Iina I Johansson Lars L Pierrou Stefan S Eriksson Olof O Velikyan Irina I
Pharmaceuticals (Basel, Switzerland) 20200731 8
<b>Introduction</b>: [<sup>68</sup>Ga]Ga-DO3A-VS-Cys<sup>40</sup>-Tuna-2 (previously published as [<sup>68</sup>Ga]Ga-DO3A-VS-Cys<sup>40</sup>-S01-GCG) has shown high-affinity specific binding to the glucagon receptor (GCGR) in vitro and in vivo in rats and non-human primates in our previous studies, confirming the suitability of the tracer for drug development applications in humans. The manufacturing process of [<sup>68</sup>Ga]Ga-DO3A-VS-Cys<sup>40</sup>-Tuna-2 was automated for clinical use ...[more]