Targeting NF-?B Signaling for Multiple Myeloma.
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ABSTRACT:
SUBMITTER: Wong AH
PROVIDER: S-EPMC7463546 | biostudies-literature | 2020 Aug
REPOSITORIES: biostudies-literature
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Targeting NF-κB Signaling for Multiple Myeloma.
Wong Ada Hang-Heng AH Shin Eun Myoung EM Tergaonkar Vinay V Chng Wee-Joo WJ
Cancers 20200806 8
Multiple myeloma (MM) is the second most common hematologic malignancy in the world. Even though survival rates have significantly risen over the past years, MM remains incurable, and is also far from reaching the point of being managed as a chronic disease. This paper reviews the evolution of MM therapies, focusing on anti-MM drugs that target the molecular mechanisms of nuclear factor kappa B (NF-κB) signaling. We also provide our perspectives on contemporary research findings and insights for ...[more]
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