Ontology highlight
ABSTRACT:
SUBMITTER: Pattappa G
PROVIDER: S-EPMC7463623 | biostudies-literature | 2020 Aug
REPOSITORIES: biostudies-literature
Pattappa Girish G Krueckel Jonas J Schewior Ruth R Franke Dustin D Mench Alexander A Koch Matthias M Weber Johannes J Lang Siegmund S Pfeifer Christian G CG Johnstone Brian B Docheva Denitsa D Alt Volker V Angele Peter P Zellner Johannes J
Biology 20200817 8
Focal early osteoarthritis (OA) or degenerative lesions account for 60% of treated cartilage defects each year. The current cell-based regenerative treatments have an increased failure rate for treating degenerative lesions compared to traumatic defects. Mesenchymal stem cells (MSCs) are an alternative cell source for treating early OA defects, due to their greater chondrogenic potential, compared to early OA chondrocytes. Low oxygen tension or physioxia has been shown to enhance MSC chondrogeni ...[more]