Ontology highlight
ABSTRACT:
SUBMITTER: Bowroju SK
PROVIDER: S-EPMC7463714 | biostudies-literature | 2020 Aug
REPOSITORIES: biostudies-literature
Bowroju Suresh K SK Mainali Nirjal N Ayyadevara Srinivas S Penthala Narsimha R NR Krishnamachari Sesha S Kakraba Samuel S Shmookler Reis Robert J RJ Crooks Peter A PA
Molecules (Basel, Switzerland) 20200808 16
A series of novel hybrid 8-hydroxyquinoline-indole derivatives (<b>7a-7e</b>, <b>12a-12b</b> and <b>18a-18h</b>) were synthesized and screened for inhibitory activity against self-induced and metal-ion induced Aβ<sub>1-42</sub> aggregation as potential treatments for Alzheimer's disease (AD). In vitro studies identified the most inhibitory compounds against self-induced Aβ<sub>1-42</sub> aggregation as <b>18c</b>, <b>18d</b> and <b>18f</b> (EC<sub>50</sub> = 1.72, 1.48 and 1.08 µM, respectively) ...[more]