MicroRNA-222 Regulates Melanoma Plasticity.
Ontology highlight
ABSTRACT:
SUBMITTER: Lionetti MC
PROVIDER: S-EPMC7464186 | biostudies-literature | 2020 Aug
REPOSITORIES: biostudies-literature
Publications
MicroRNA-222 Regulates Melanoma Plasticity.
Lionetti Maria Chiara MC Cola Filippo F Chepizhko Oleksandr O Fumagalli Maria Rita MR Font-Clos Francesc F Ravasio Roberto R Minucci Saverio S Canzano Paola P Camera Marina M Tiana Guido G Zapperi Stefano S Porta Caterina A M La CAM
Journal of clinical medicine 20200808 8
Melanoma is one of the most aggressive and highly resistant tumors. Cell plasticity in melanoma is one of the main culprits behind its metastatic capabilities. The detailed molecular mechanisms controlling melanoma plasticity are still not completely understood. Here we combine mathematical models of phenotypic switching with experiments on IgR39 human melanoma cells to identify possible key targets to impair phenotypic switching. Our mathematical model shows that a cancer stem cell subpopulatio ...[more]
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