Ontology highlight
ABSTRACT:
SUBMITTER: Valable S
PROVIDER: S-EPMC7464439 | biostudies-literature | 2020 Jul
REPOSITORIES: biostudies-literature
Valable Samuel S Gérault Aurélie N AN Lambert Gaëlle G Leblond Marine M MM Anfray Clément C Toutain Jérôme J Bordji Karim K Petit Edwige E Bernaudin Myriam M Pérès Elodie A EA
Cancers 20200723 8
Tumor hypoxia is known to limit the efficacy of ionizing radiations, a concept called oxygen enhancement ratio (OER). OER depends on physical factors such as pO<sub>2</sub> and linear energy transfer (LET). Biological pathways, such as the hypoxia-inducible transcription factors (HIF), might also modulate the influence of LET on OER. Glioblastoma (GB) is resistant to low-LET radiation (X-rays), due in part to the hypoxic environment in this brain tumor. Here, we aim to evaluate in vitro whether ...[more]