Dataset Information

Dyeing and Antibacterial Properties of Chemically Recycled PET Thermal-Bonded Nonwovens Dyed with Terminalia chebula Dye.

ABSTRACT: Waste recycling is a necessary step for environmental conservation. To this end, polyester can be easily collected and recycled into end products. To promote the use of recycled polyester, it is important to expand its range of applications. We earlier reported the fabrication of recycled polyester thermal-bonded nonwovens. In this study, recycled nonwoven fabrics were dyed with Terminalia chebula dye without the use of additional mordants. To optimize the dyeing conditions, the dyeing time, dyeing temperature, and liquor concentration were varied, and the color strength, color changes, fastness properties, thermal stability, and morphology were evaluated. Further, the antibacterial activity of the dyed nonwoven was also estimated. T. chebula dyed the colored recycled rapid melting PET fiber (R-RM) nonwoven brown via the dyeing process, and the dyeablity was improved by increasing the dyeing temperature, time, and liquor concentration. The rubbing and sweat fastness properties were found to be excellent. T. chebula dye imparted efficient antibacterial properties to the R-RM nonwovens against Staphylococcus aureus and Klebsiella pneumonia. The results obtained in this study are expected to broaden the range of natural dyed recycled polyester fabric applications.

SUBMITTER: Lee JH

PROVIDER: S-EPMC7464636 | biostudies-literature | 2020 Jul

REPOSITORIES: biostudies-literature

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Dyeing and Antibacterial Properties of Chemically Recycled PET Thermal-Bonded Nonwovens Dyed with <i>Terminalia chebula</i> Dye.

Lee Joo Hyung JH Jung Jong Sun JS Kim Seong Hun SH

Polymers 20200727 8

Waste recycling is a necessary step for environmental conservation. To this end, polyester can be easily collected and recycled into end products. To promote the use of recycled polyester, it is important to expand its range of applications. We earlier reported the fabrication of recycled polyester thermal-bonded nonwovens. In this study, recycled nonwoven fabrics were dyed with Terminalia chebula dye without the use of additional mordants. To optimize the dyeing conditions, the dyeing time, dye ...[more]

PMID: 32727160

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Project description:Background:Alzheimer's disease (AD) is a progressive neurodegenerative disorder clinically characterized by memory loss and impaired cognitive function. Cholinergic enzyme deficiency and oxidative stress are the two major factors implicated in the pathogenesis of AD. The symptomatic treatment, as of now, is the use of cholinesterase inhibitors toward cholinergic "downturn." Therefore, there is a search for compounds that will be useful in focused therapies. There has been suggestion that Terminalia chebula fruit would be a potential source. Objective:To assess the anticholinesterase and antioxidant activities of T. chebula fruit which is widely practiced in the Ayurvedic medicines for memory enhancement. Materials and Methods:Ethyl acetate extract of T. chebula fruit (TCEA) was subjected to phytochemical investigation of acetylcholinesterase (AChE) and butyrylcholinesterase (BuChE) inhibitory activities and cell-free antioxidant activity. TCEA was further subjected to gas chromatography-mass spectrum (GC-MS) analysis. The bioactive compounds were analyzed for molecular docking with AChE and BuChE proteins. Results:TCEA exhibited potent AChE and BuChE inhibitory activities comparable to the standard drug donepezil. In vitro cell-free antioxidant assays demonstrated that TCEA possesses excellent free radical scavenging activity, reducing power, and potent metal-chelating activity. Total polyphenolic content of TCEA was 596.75 ± 0.35 µg gallic acid equivalents/mg of extract, which correlates with the antioxidant activity of TCEA. Molecular docking of compounds expounded in GC-MS analysis for AChE and BuChE enzyme activities revealed that methyl N-(N-benzyloxycarbonyl-beta-l-aspartyl)-beta-d-glucosaminide as the most potent compound with good predicted activities. Conclusion:Overall, the results revealed that the bioactive molecule methyl N-(N-benzyloxycarbonyl-beta-l-aspartyl)-beta-d-glucosaminide present in TCEA is a potential depressant for the treatment of AD and related neurodegenerative disorders. SUMMARY:The present study was carried out to assess the neuroprotective effect of Terminalia chebula fruit and its phytoconstituent. Phytochemical analysis of fruit ethyl acetate extract of T. chebula (TCEA) showed the presence of alkaloid, cardiac glycoside, and tannin. TCEA showed potent acetylcholinesterase (AChE) and butyrylcholinesterase (BuChE) inhibitory activities when compared to standard drug donepezil. Results of in vitro antioxidant assays revealed excellent free radical scavenging activity, reducing power, and potent metal-chelating activity. Gas chromatography-mass spectrum analysis illustrated the presence of 22 active compounds, among which methyl N-(N-benzyloxycarbonyl-beta-l-aspartyl)-beta-d-glucosaminide exhibited potent AChE and BuChE inhibition analyzed through in silico studies. Abbreviations used: AD: Alzheimer's disease; TCEA: Ethyl acetate extract of Terminalia chebula; GC-MS: Gas chromatography-mass spectrum; ROS: Reactive oxygen species; RNS: Reactive nitrogen species; AChE: Acetylcholinesterase; BuChE: Butyrylcholinesterase; NFT: Neurofibrillary tangles; A?: ?-amyloid; NSAIDS: Nonsteroidal anti-inflammatory drugs; FDA: Food and Drug Administration; RT: Room temperature; HCl: Hydrochloric acid; ATCI: Acetylthiocholine iodide; BTCI: Butyrylthiocholine iodide; BHT: Butylated hydroxytoluene; DPPH: 2,2-diphenyl-1-picrylhydrazyl; TCA: Trichloroacetic acid; GAE: Gallic acid equivalent; NICT: National Institute of Information and Communications Technology; 3D: Three-dimensional; PDB: Protein data bank; OPLS: Optimized potentials for liquid simulations; XP: Extra precision; SD: Standard deviation; ANOVA: Analysis of variance; EDTA: Ethylenediaminetetraacetic acid.

Project description:BackgroundBurgeoning antibiotic resistance in Pseudomonas aeruginosa has necessitated the development of anti pathogenic agents that can quench acylhomoserine lactone (AHL) mediated QS with least risk of resistance. This study explores the anti quorum sensing potential of T. chebula Retz. and identification of probable compounds(s) showing anti QS activity and the mechanism of attenuation of P. aeruginosa PAO1 virulence factors.Methods and resultsMethanol extract of T. chebula Retz. fruit showed anti QS activity using Agrobacterium tumefaciens A136. Bioactive fraction (F7), obtained by fractionation of methanol extract using Sephadex LH20, showed significant reduction (p<0.001) in QS regulated production of extracellular virulence factors in P. aeruginosa PAO1. Biofilm formation and alginate were significantly (p<0.05) reduced with enhanced (20%) susceptibility to tobramycin. Real Time PCR of F7 treated P. aeruginosa showed down regulation of autoinducer synthase (lasI and rhlI) and their cognate receptor (lasR and rhlR) genes by 89, 90, 90 and 93%, respectively. Electrospray Ionization Mass Spectrometry also showed 90 and 64% reduction in the production of 3-oxo-C(12)HSL and C(4)HSL after treatment. Decrease in AHLs as one of the mechanisms of quorum quenching by F7 was supported by the reversal of inhibited swarming motility in F7-treated P. aeruginosa PAO1 on addition of C(4)HSL. F7 also showed antagonistic activity against 3-oxo-C(12)HSL-dependent QS in E. coli bioreporter. C. elegans fed on F7-treated P. aeruginosa showed enhanced survival with LT50 increasing from 24 to 72 h. LC-ESI-MS of F7 revealed the presence of ellagic acid derivatives responsible for anti QS activity in T. chebula extract.ConclusionsThis is the first report on anti QS activity of T. chebula fruit linked to EADs which down regulate the expression of lasIR and rhlIR genes with concomitant decrease in AHLs in P. aeruginosa PAO1 causing attenuation of its virulence factors and enhanced sensitivity of its biofilm towards tobramycin.

Dataset Information

Dyeing and Antibacterial Properties of Chemically Recycled PET Thermal-Bonded Nonwovens Dyed with Terminalia chebula Dye.

Publications

Dyeing and Antibacterial Properties of Chemically Recycled PET Thermal-Bonded Nonwovens Dyed with <i>Terminalia chebula</i> Dye.

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