Ontology highlight
ABSTRACT:
SUBMITTER: Mietus CJ
PROVIDER: S-EPMC7464726 | biostudies-literature | 2020 Aug
REPOSITORIES: biostudies-literature
Mietus Constance J CJ Lackner Timothy J TJ Karvelis Petros S PS Willcockson Gregory T GT Shields Christina M CM Lambert Nicholas G NG Koutakis Panagiotis P Fuglestad Matthew A MA Hernandez Hernan H Haynatzki Gleb R GR Kim Julian K S JKS DeSpiegelaere Holly K HK Pipinos Iraklis I II Casale George P GP
Journal of clinical medicine 20200808 8
Work from our laboratory documents pathological events, including myofiber oxidative damage and degeneration, myofibrosis, micro-vessel (diameter = 50-150 μm) remodeling, and collagenous investment of terminal micro-vessels (diameter ≤ 15 µm) in the calf muscle of patients with Peripheral Artery Disease (PAD). In this study, we evaluate the hypothesis that the vascular pathology associated with the legs of PAD patients encompasses pathologic changes to the smallest micro-vessels in calf muscle. ...[more]