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Early Intervention in Ulcerative Colitis: Ready for Prime Time?

ABSTRACT: Growing evidence shows that ulcerative colitis (UC) is a progressive disease similar to Crohn's disease (CD). The UC-related burden is often underestimated by physicians and a standard step-up therapeutic approach is preferred. However, in many patients with UC the disease activity is not adequately controlled by current management, leading to poor long-term prognosis. Data from both randomized controlled trials and real-world studies support early intervention in CD in order to prevent disease progression and irreversible bowel damage. Similarly, an early disease intervention during the so-called "window of opportunity" could lead to better outcomes in UC. Here, we summarize the literature evidence on early intervention in patients with UC, highlighting strengths and limitations of this approach.

SUBMITTER: Solitano V

PROVIDER: S-EPMC7464940 | biostudies-literature | 2020 Aug

REPOSITORIES: biostudies-literature

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Early Intervention in Ulcerative Colitis: Ready for Prime Time?

Solitano Virginia V D'Amico Ferdinando F Zacharopoulou Eirini E Peyrin-Biroulet Laurent L Danese Silvio S

Journal of clinical medicine 20200814 8

Growing evidence shows that ulcerative colitis (UC) is a progressive disease similar to Crohn's disease (CD). The UC-related burden is often underestimated by physicians and a standard step-up therapeutic approach is preferred. However, in many patients with UC the disease activity is not adequately controlled by current management, leading to poor long-term prognosis. Data from both randomized controlled trials and real-world studies support early intervention in CD in order to prevent disease ...[more]

PMID: 32823997

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