Ontology highlight
ABSTRACT:
SUBMITTER: Shihab I
PROVIDER: S-EPMC7464944 | biostudies-literature | 2020 Aug
REPOSITORIES: biostudies-literature
Shihab Israa I Khalil Bariaa A BA Elemam Noha Mousaad NM Hachim Ibrahim Y IY Hachim Mahmood Yaseen MY Hamoudi Rifat A RA Maghazachi Azzam A AA
Cancers 20200809 8
The innate immune system is the first line of defense against invading pathogens and has a major role in clearing transformed cells, besides its essential role in activating the adaptive immune system. Macrophages, dendritic cells, NK cells, and granulocytes are part of the innate immune system that accumulate in the tumor microenvironment such as breast cancer. These cells induce inflammation in situ by secreting cytokines and chemokines that promote tumor growth and progression, in addition to ...[more]