Unknown

Dataset Information

0

Cashew (Anacardium occidentale L.) Nuts Counteract Oxidative Stress and Inflammation in an Acute Experimental Model of Carrageenan-Induced Paw Edema.


ABSTRACT: BACKGROUND:Anacardium occidentale L. is a medicinal plant with powerful anti-oxidative and anti-inflammatory properties. Acute inflammatory events cause tissue alterations, decrease of anti-oxidative endogenous enzymes such as superoxide dismutase, catalase and glutathione, neutrophils infiltration, increase in the activities of myeloperoxidase, malondialdehyde, and pro-inflammatory release. METHODS:Paw edema was induced by subplantar injection of carrageenan into the right hind paw in rats, but 30 min before a group of animals were orally treated with 100 mg/kg of cashew nuts to evaluate the anti-inflammatory and anti-oxidative response. RESULTS:In the present work, we found that (1) cashew nuts reduced the development of carrageenan-induced paw edema limiting the formation of edema and pain; (2) cashew nuts ameliorated the diminutions of the anti-oxidative enzymes caused by carrageenan injection; (3) cashew nuts decreased myeloperoxidase malondialdehyde activity induced by carrageenan; and (4) cashew nuts acted by blocking pro-inflammatory cytokines response and nitrate/nitrite formation stimulated by carrageenan injection. CONCLUSIONS:The mechanisms of anti-inflammatory and analgesic effects exerted by cashew nuts were relevant to oxygen free radical scavenging, anti-lipid peroxidation, and inhibition of the formation of inflammatory cytokines.

SUBMITTER: Cordaro M 

PROVIDER: S-EPMC7465066 | biostudies-literature | 2020 Jul

REPOSITORIES: biostudies-literature

altmetric image

Publications

Cashew (<i>Anacardium occidentale</i> L.) Nuts Counteract Oxidative Stress and Inflammation in an Acute Experimental Model of Carrageenan-Induced Paw Edema.

Cordaro Marika M   Siracusa Rosalba R   Fusco Roberta R   D'Amico Ramona R   Peritore Alessio Filippo AF   Gugliandolo Enrico E   Genovese Tiziana T   Scuto Maria M   Crupi Rosalia R   Mandalari Giuseppina G   Cuzzocrea Salvatore S   Di Paola Rosanna R   Impellizzeri Daniela D  

Antioxidants (Basel, Switzerland) 20200724 8


<h4>Background</h4><i>Anacardium occidentale</i> L. is a medicinal plant with powerful anti-oxidative and anti-inflammatory properties. Acute inflammatory events cause tissue alterations, decrease of anti-oxidative endogenous enzymes such as superoxide dismutase, catalase and glutathione, neutrophils infiltration, increase in the activities of myeloperoxidase, malondialdehyde, and pro-inflammatory release.<h4>Methods</h4>Paw edema was induced by subplantar injection of carrageenan into the right  ...[more]

Similar Datasets

| S-EPMC6907795 | biostudies-literature
| S-EPMC7582295 | biostudies-literature
| S-EPMC7602264 | biostudies-literature
| S-EPMC10808333 | biostudies-literature
| S-EPMC7180418 | biostudies-literature
| S-EPMC11311269 | biostudies-literature
| PRJNA671544 | ENA
| PRJNA785040 | ENA
| S-EPMC5932493 | biostudies-other
| S-EPMC7847839 | biostudies-literature