Ontology highlight
ABSTRACT:
SUBMITTER: Serena C
PROVIDER: S-EPMC7465250 | biostudies-literature | 2020 Jul
REPOSITORIES: biostudies-literature
Serena Carolina C Queipo-Ortuño Maribel M Millan Monica M Sanchez-Alcoholado Lidia L Caro Aleidis A Espina Beatriz B Menacho Margarita M Bautista Michelle M Monfort-Ferré Diandra D Terrón-Puig Margarida M Núñez-Roa Catalina C Maymó-Masip Elsa E Rodriguez M Mar MM Tinahones Francisco J FJ Espin Eloy E Martí Marc M Fernández-Veledo Sonia S Vendrell Joan J
Journal of clinical medicine 20200731 8
Crohn's disease (CD) is characterized by compromised immune tolerance to the intestinal commensal microbiota, intestinal barrier inflammation, and hyperplasia of creeping fat (CF) and mesenteric adipose tissue (AT), which seems to be directly related to disease activity. Gut microbiota dysbiosis might be a determining factor in CD etiology, manifesting as a low microbial diversity and a high abundance of potentially pathogenic bacteria. We tested the hypothesis that CF is a reservoir of bacteria ...[more]