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Robustness during Aging-Molecular Biological and Physiological Aspects.

ABSTRACT: Understanding the process of aging is still an important challenge to enable healthy aging and to prevent age-related diseases. Most studies in age research investigate the decline in organ functionality and gene activity with age. The focus on decline can even be considered a paradigm in that field. However, there are certain aspects that remain surprisingly stable and keep the organism robust. Here, we present and discuss various properties of robust behavior during human and animal aging, including physiological and molecular biological features, such as the hematocrit, body temperature, immunity against infectious diseases and others. We examine, in the context of robustness, the different theories of how aging occurs. We regard the role of aging in the light of evolution.

SUBMITTER: Barth E

PROVIDER: S-EPMC7465392 | biostudies-literature | 2020 Aug

REPOSITORIES: biostudies-literature

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Robustness during Aging-Molecular Biological and Physiological Aspects.

Barth Emanuel E Sieber Patricia P Stark Heiko H Schuster Stefan S

Cells 20200808 8

Understanding the process of aging is still an important challenge to enable healthy aging and to prevent age-related diseases. Most studies in age research investigate the decline in organ functionality and gene activity with age. The focus on decline can even be considered a paradigm in that field. However, there are certain aspects that remain surprisingly stable and keep the organism robust. Here, we present and discuss various properties of robust behavior during human and animal aging, inc ...[more]

PMID: 32784503

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Project description:BackgroundIndividual differences in the rate of aging and susceptibility to disease are not accounted for by chronological age alone. These individual differences are better explained by biological age, which may be estimated by biomarker prediction models. In the light of the aging demographics of the global population and the increase in lifestyle-related morbidities, it is interesting to invent a new biological age model to be used for health promotion.ObjectiveThis study aims to develop a model that estimates biological age based on physiological biomarkers of healthy aging.MethodsCarefully selected physiological variables from a healthy study population of 100 women and men were used as biomarkers to establish an estimate of biological age. Principal component analysis was applied to the biomarkers and the first principal component was used to define the algorithm estimating biological age.ResultsThe first principal component accounted for 31% in women and 25% in men of the total variance in the biological age model combining mean arterial pressure, glycated hemoglobin, waist circumference, forced expiratory volume in 1 second, maximal oxygen consumption, adiponectin, high-density lipoprotein, total cholesterol, and soluble urokinase-type plasminogen activator receptor. The correlation between the corrected biological age and chronological age was r=0.86 (P<.001) and r=0.81 (P<.001) for women and men, respectively, and the agreement was high and unbiased. No difference was found between mean chronological age and mean biological age, and the slope of the regression line was near 1 for both sexes.ConclusionsEstimating biological age from these 9 biomarkers of aging can be used to assess general health compared with the healthy aging trajectory. This may be useful to evaluate health interventions and as an aid to enhance awareness of individual health risks and behavior when deviating from this trajectory.Trial registrationClinicalTrials.gov NCT03680768; https://clinicaltrials.gov/ct2/show/NCT03680768.International registered report identifier (irrid)RR2-10.2196/19209.

Dataset Information

Robustness during Aging-Molecular Biological and Physiological Aspects.

Publications

Robustness during Aging-Molecular Biological and Physiological Aspects.

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