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Naturally-Occurring Alkaloids of Plant Origin as Potential Antimicrobials against Antibiotic-Resistant Infections.


ABSTRACT: Antibiotic resistance is now considered a worldwide problem that puts public health at risk. The onset of bacterial strains resistant to conventional antibiotics and the scarcity of new drugs have prompted scientific research to re-evaluate natural products as molecules with high biological and chemical potential. A class of natural compounds of significant importance is represented by alkaloids derived from higher plants. In this review, we have collected data obtained from various research groups on the antimicrobial activities of these alkaloids against conventional antibiotic-resistant strains. In addition, the structure-function relationship was described and commented on, highlighting the high potential of alkaloids as antimicrobials.

SUBMITTER: Casciaro B 

PROVIDER: S-EPMC7466045 | biostudies-literature | 2020 Aug

REPOSITORIES: biostudies-literature

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Naturally-Occurring Alkaloids of Plant Origin as Potential Antimicrobials against Antibiotic-Resistant Infections.

Casciaro Bruno B   Mangiardi Laura L   Cappiello Floriana F   Romeo Isabella I   Loffredo Maria Rosa MR   Iazzetti Antonia A   Calcaterra Andrea A   Goggiamani Antonella A   Ghirga Francesca F   Mangoni Maria Luisa ML   Botta Bruno B   Quaglio Deborah D  

Molecules (Basel, Switzerland) 20200809 16


Antibiotic resistance is now considered a worldwide problem that puts public health at risk. The onset of bacterial strains resistant to conventional antibiotics and the scarcity of new drugs have prompted scientific research to re-evaluate natural products as molecules with high biological and chemical potential. A class of natural compounds of significant importance is represented by alkaloids derived from higher plants. In this review, we have collected data obtained from various research gro  ...[more]

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