Ontology highlight
ABSTRACT:
SUBMITTER: Edwards AM
PROVIDER: S-EPMC7466049 | biostudies-literature | 2020 Aug
REPOSITORIES: biostudies-literature
Edwards Ashley M AM Addo Maame A MA Dos Santos Patricia C PC
Genes 20200807 8
Transfer RNAs (tRNAs) are essential adaptors that mediate translation of the genetic code. These molecules undergo a variety of post-transcriptional modifications, which expand their chemical reactivity while influencing their structure, stability, and functionality. Chemical modifications to tRNA ensure translational competency and promote cellular viability. Hence, the placement and prevalence of tRNA modifications affects the efficiency of aminoacyl tRNA synthetase (aaRS) reactions, interacti ...[more]