Anti-Metastasis Fascin Inhibitors Decrease the Growth of Specific Subtypes of Cancers.
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ABSTRACT:
SUBMITTER: Wang Y
PROVIDER: S-EPMC7466159 | biostudies-literature | 2020 Aug
REPOSITORIES: biostudies-literature
Publications
Anti-Metastasis Fascin Inhibitors Decrease the Growth of Specific Subtypes of Cancers.
Wang Yufeng Y Zhang J Jillian JJ Huang Xin-Yun XY
Cancers 20200814 8
Fascin is an actin-bundling protein that is critical for filopodial formation and other cellular cytoskeletal structures. An elevated expression of fascin has been observed in tumor cells and is correlated with a shorter survival of cancer patients. Given its roles in tumor cell migration and invasion, we have developed small-molecule fascin inhibitors to prevent and delay tumor metastasis. Here we report the characterization of a new fascin inhibitor in mice. In addition to its inhibitory effec ...[more]
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