Mathematical Modeling of MPNs Offers Understanding and Decision Support for Personalized Treatment.
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ABSTRACT:
SUBMITTER: Ottesen JT
PROVIDER: S-EPMC7466162 | biostudies-literature | 2020 Jul
REPOSITORIES: biostudies-literature
Publications
Mathematical Modeling of MPNs Offers Understanding and Decision Support for Personalized Treatment.
Ottesen Johnny T JT Pedersen Rasmus K RK Dam Marc J B MJB Knudsen Trine A TA Skov Vibe V Kjær Lasse L Andersen Morten M
Cancers 20200730 8
(1) Background: myeloproliferative neoplasms (MPNs) are slowly developing hematological cancers characterized by few driver mutations, with <i>JAK2</i>V617F being the most prevalent. (2) Methods: using mechanism-based mathematical modeling (MM) of hematopoietic stem cells, mutated hematopoietic stem cells, differentiated blood cells, and immune response along with longitudinal data from the randomized Danish DALIAH trial, we investigate the effect of the treatment of MPNs with interferon-α2 on d ...[more]
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