Ontology highlight
ABSTRACT:
SUBMITTER: Anoshkin KI
PROVIDER: S-EPMC7466669 | biostudies-literature | 2020
REPOSITORIES: biostudies-literature
Frontiers in oncology 20200819
We present the genetic profile of kidney giant leiomyosarcoma characterized by sequencing of 409 cancer related genes and chromosomal microarray analysis. Renal leiomyosarcomas are extremely rare neoplasms with aggressive behavior and poor survival prognosis. Most frequent somatic events in leiomyosarcomas are mutations in the TP53, RB1, ATRX, and PTEN genes, chromosomal instability (CIN) and chromoanagenesis. 67-year-old woman presented with a right kidney completely replaced by tumor. Immunohi ...[more]