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Roadmap to Building a Cell: An Evolutionary Approach.


ABSTRACT: Laboratory synthesis of an elementary biological cell from isolated components may aid in understanding of the fundamental principles of life and will provide a platform for a range of bioengineering and medical applications. In essence, building a cell consists in the integration of cellular modules into system's level functionalities satisfying a definition of life. To achieve this goal, we propose in this perspective to undertake a semi-rational, system's level evolutionary approach. The strategy would require iterative cycles of genetic integration of functional modules, diversification of hereditary information, compartmentalized gene expression, selection/screening, and possibly, assistance from open-ended evolution. We explore the underlying challenges to each of these steps and discuss possible solutions toward the bottom-up construction of an artificial living cell.

SUBMITTER: Abil Z 

PROVIDER: S-EPMC7466671 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature

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Roadmap to Building a Cell: An Evolutionary Approach.

Abil Zhanar Z   Danelon Christophe C  

Frontiers in bioengineering and biotechnology 20200819


Laboratory synthesis of an elementary biological cell from isolated components may aid in understanding of the fundamental principles of life and will provide a platform for a range of bioengineering and medical applications. In essence, building a cell consists in the integration of cellular modules into system's level functionalities satisfying <i>a</i> definition of life. To achieve this goal, we propose in this perspective to undertake a semi-rational, system's level evolutionary approach. T  ...[more]

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