Ontology highlight
ABSTRACT:
SUBMITTER: Cai TT
PROVIDER: S-EPMC7466761 | biostudies-literature | 2020
REPOSITORIES: biostudies-literature
Cai Ting-Ting TT Ye Xiao-Long XL Li Ru-Run RR Chen Hui H Wang Ya-Yun YY Yong Hui-Juan HJ Pan Ming-Lin ML Lu Wei W Tang Ying Y Miao Heng H Snijders Antoine M AM Mao Jian-Hua JH Liu Xing-Yin XY Lu Yi-Bing YB Ding Da-Fa DF
Frontiers in pharmacology 20200819
Oral administration of resveratrol is able to ameliorate the progression of diabetic nephropathy (DN); however, its mechanisms of action remain unclear. Recent evidence suggested that the gut microbiota is involved in the metabolism therapeutics. In the current study, we sought to determine whether the anti-DN effects of resveratrol are mediated through modulation of the gut microbiota using the genetic db/db mouse model of DN. We demonstrate that resveratrol treatment of db/db mice relieves a s ...[more]