Ontology highlight
ABSTRACT:
SUBMITTER: Ellison MA
PROVIDER: S-EPMC7466961 | biostudies-literature | 2020 Sep
REPOSITORIES: biostudies-literature
Ellison Mitchell A MA Walker Jennifer L JL Ropp Patrick J PJ Durrant Jacob D JD Arndt Karen M KM
G3 (Bethesda, Md.) 20200902 9
MutantHuntWGS is a user-friendly pipeline for analyzing <i>Saccharomyces cerevisiae</i> whole-genome sequencing data. It uses available open-source programs to: (1) perform sequence alignments for paired and single-end reads, (2) call variants, and (3) predict variant effect and severity. MutantHuntWGS outputs a shortlist of variants while also enabling access to all intermediate files. To demonstrate its utility, we use MutantHuntWGS to assess multiple published datasets; in all cases, it detec ...[more]