Ontology highlight
ABSTRACT:
SUBMITTER: Ma J
PROVIDER: S-EPMC7467232 | biostudies-literature | 2020 Jul
REPOSITORIES: biostudies-literature
Ma Jing J Jiang Xinghao X Yarui An A Danli Jin J Xiaodie Yin Y Zhang Jian J Xu Ajing A
Toxicology research 20200713 4
P38 mitogen-activated protein kinase (p38 MAPK) plays an important role in innate immunity and is activated by ultraviolet (UV) radiation. However, the molecular mechanism underlying UV stress remains unclear. In this study, we reported that UV activated PMK-1/p38 MAPK signaling via JKK-1 and MOM-4 in <i>Caenorhabditis elegans</i>. In <i>C. elegans</i>, different UV radiation doses resulted in PMK-1 phosphorylation. However, pmk-1 mutants failed to demonstrate an altered survival time in respons ...[more]