Ontology highlight
ABSTRACT:
SUBMITTER: Nguyen TD
PROVIDER: S-EPMC7467569 | biostudies-literature | 2020 Jul
REPOSITORIES: biostudies-literature
ACS chemical biology 20200611 7
Iridoids are plant-derived terpenoids with a rich array of bioactivities. The key step in iridoid skeleton formation is the reduction of 8-oxogeranial by certain members of the progesterone 5β-reductase/iridoid synthase (PRISE) family of short-chain alcohol dehydrogenases. Other members of the PRISE family have previously been implicated in the biosynthesis of the triterpenoid class of cardenolides, which requires the reduction of progesterone. Here, we explore the occurrence and activity of PRI ...[more]