Model for the Analysis of Membrane-Type Dissolution Tests for Inhaled Drugs.
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ABSTRACT:
SUBMITTER: Frenning G
PROVIDER: S-EPMC7467770 | biostudies-literature | 2020 Jul
REPOSITORIES: biostudies-literature
Publications
Model for the Analysis of Membrane-Type Dissolution Tests for Inhaled Drugs.
Frenning Göran G van der Zwaan Irès I Franek Frans F Fransson Rebecca R Tehler Ulrika U
Molecular pharmaceutics 20200615 7
Impactor-type dose deposition is a common prerequisite for dissolution testing of inhaled medicines, and drug release typically takes place through a membrane. The purpose of this work is to develop a mechanistic model for such combined dissolution and release processes, focusing on a drug that initially is present in solid form. Our starting points are the Noyes-Whitney (or Nernst-Brunner) equation and Fick's law. A detailed mechanistic analysis of the drug release process is provided, and appr ...[more]
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