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Deep Brain Stimulation in the Nucleus Accumbens for Binge Eating Disorder: a Study in Rats.

ABSTRACT: Binge eating disorder (BED), with its compulsive and addictive components, may often underlie weight regain after gastrointestinal bariatric surgeries. BED is therefore considered an exclusion criterion for these surgeries. Anecdotal reports suggest that deep brain stimulation (DBS) is an effective treatment for addictive disorders with, similar to BED, pathological changes in cerebral reward circuitry. We therefore assessed effect of DBS of the nucleus accumbens (NAC) in a rat model of BED. Twenty-one male obesity prone Wistar rats with DBS electrodes placed in NAC subregions were subjected to a binge eating protocol. Binge eating was significantly reduced with DBS during (NAC core) or before (NAC lateral shell) the binge. These outcomes provide a base to further explore the potential of DBS in the treatment of BED.

SUBMITTER: Oterdoom DLM

PROVIDER: S-EPMC7467950 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature

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Deep Brain Stimulation in the Nucleus Accumbens for Binge Eating Disorder: a Study in Rats.

Oterdoom D L Marinus DLM Lok Renske R van Beek André P AP den Dunnen Wilfred F A WFA Emous Marloes M van Dijk J Marc C JMC van Dijk Gertjan G

Obesity surgery 20201001 10

Binge eating disorder (BED), with its compulsive and addictive components, may often underlie weight regain after gastrointestinal bariatric surgeries. BED is therefore considered an exclusion criterion for these surgeries. Anecdotal reports suggest that deep brain stimulation (DBS) is an effective treatment for addictive disorders with, similar to BED, pathological changes in cerebral reward circuitry. We therefore assessed effect of DBS of the nucleus accumbens (NAC) in a rat model of BED. Twe ...[more]

PMID: 32451916

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