Unknown

Dataset Information

0

FGF/FGFR signaling in health and disease.


ABSTRACT: Growing evidences suggest that the fibroblast growth factor/FGF receptor (FGF/FGFR) signaling has crucial roles in a multitude of processes during embryonic development and adult homeostasis by regulating cellular lineage commitment, differentiation, proliferation, and apoptosis of various types of cells. In this review, we provide a comprehensive overview of the current understanding of FGF signaling and its roles in organ development, injury repair, and the pathophysiology of spectrum of diseases, which is a consequence of FGF signaling dysregulation, including cancers and chronic kidney disease (CKD). In this context, the agonists and antagonists for FGF-FGFRs might have therapeutic benefits in multiple systems.

SUBMITTER: Xie Y 

PROVIDER: S-EPMC7468161 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature

altmetric image

Publications


Growing evidences suggest that the fibroblast growth factor/FGF receptor (FGF/FGFR) signaling has crucial roles in a multitude of processes during embryonic development and adult homeostasis by regulating cellular lineage commitment, differentiation, proliferation, and apoptosis of various types of cells. In this review, we provide a comprehensive overview of the current understanding of FGF signaling and its roles in organ development, injury repair, and the pathophysiology of spectrum of disea  ...[more]

Similar Datasets

| S-EPMC5129976 | biostudies-literature
| S-EPMC8002748 | biostudies-literature
| S-EPMC10039534 | biostudies-literature
| S-EPMC8764167 | biostudies-literature
| S-EPMC9503799 | biostudies-literature
| S-EPMC4472122 | biostudies-other
| S-EPMC3900324 | biostudies-literature
| S-EPMC5925806 | biostudies-other
| S-EPMC3203899 | biostudies-literature
| S-EPMC3753266 | biostudies-literature