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FGF/FGFR signaling in health and disease.

ABSTRACT: Growing evidences suggest that the fibroblast growth factor/FGF receptor (FGF/FGFR) signaling has crucial roles in a multitude of processes during embryonic development and adult homeostasis by regulating cellular lineage commitment, differentiation, proliferation, and apoptosis of various types of cells. In this review, we provide a comprehensive overview of the current understanding of FGF signaling and its roles in organ development, injury repair, and the pathophysiology of spectrum of diseases, which is a consequence of FGF signaling dysregulation, including cancers and chronic kidney disease (CKD). In this context, the agonists and antagonists for FGF-FGFRs might have therapeutic benefits in multiple systems.

SUBMITTER: Xie Y

PROVIDER: S-EPMC7468161 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature

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FGF/FGFR signaling in health and disease.

Xie Yangli Y Su Nan N Yang Jing J Tan Qiaoyan Q Huang Shuo S Jin Min M Ni Zhenhong Z Zhang Bin B Zhang Dali D Luo Fengtao F Chen Hangang H Sun Xianding X Feng Jian Q JQ Qi Huabing H Chen Lin L

Signal transduction and targeted therapy 20200902 1

Growing evidences suggest that the fibroblast growth factor/FGF receptor (FGF/FGFR) signaling has crucial roles in a multitude of processes during embryonic development and adult homeostasis by regulating cellular lineage commitment, differentiation, proliferation, and apoptosis of various types of cells. In this review, we provide a comprehensive overview of the current understanding of FGF signaling and its roles in organ development, injury repair, and the pathophysiology of spectrum of disea ...[more]

PMID: 32879300

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