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Hepatitis C virus infection characteristics and treatment outcomes in Canadian immigrants.


ABSTRACT: BACKGROUND:There are multiple obstacles encountered by immigrants attempting to engage hepatitis C virus (HCV) care and treatment. We evaluated the diversity and treatment outcomes of HCV-infected immigrants evaluated for Direct Acting Antiviral (DAA) therapy in Canada. METHODS:The Canadian Network Undertaking against Hepatitis C (CANUHC) Cohort contains demographic information and DAA treatment information prospectively collected at 10 Canadian sites. Information on country of origin and race are collected. Characteristics and outcomes (sustained virological response; SVR) were compared by immigration status and race. RESULTS:Between January 2016 and May 2018, 725 HCV-infected patients assessed for DAA therapy were enrolled in CANUHC (mean age: 52.66?±?12.68?years); 65.66% male; 82.08% White, 5.28% Indigenous, 4.64% South East Asian, 4.64% East Indian, 3.36% Black). 18.48% were born outside of Canada. Mean age was similar [immigrants: 54.36?±?13.95?years), Canadian-born: 52.27?±?12.35?years); (p?=?0.085)]. The overall baseline fibrosis score (in kPa measured by transient elastography) was similar among Canadian and foreign-born patients. Fibrosis score was not predicted by race or genotype. The proportion initiating DAA therapy was similar by immigrant status (56.72% vs 49.92%). SVR rates by intent-to-treat analysis were similar (immigrants-89.47%, Canadian-born-92.52%; p?=?0.575). CONCLUSION:A diverse immigrant population is engaging care in Canada, initiating HCV antiviral therapy in an equitable fashion and achieving SVR proportions similar to Canada-born patients. Our Canadian experience may be of value in informing HCV elimination efforts in economically developed regions.

SUBMITTER: Cooper CL 

PROVIDER: S-EPMC7469277 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature

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Hepatitis C virus infection characteristics and treatment outcomes in Canadian immigrants.

Cooper Curtis L CL   Read Daniel D   Vachon Marie-Louise ML   Conway Brian B   Wong Alexander A   Ramji Alnoor A   Borgia Sergio S   Tam Ed E   Barrett Lisa L   Smyth Dan D   Feld Jordan J JJ   Lee Sam S  

BMC public health 20200903 1


<h4>Background</h4>There are multiple obstacles encountered by immigrants attempting to engage hepatitis C virus (HCV) care and treatment. We evaluated the diversity and treatment outcomes of HCV-infected immigrants evaluated for Direct Acting Antiviral (DAA) therapy in Canada.<h4>Methods</h4>The Canadian Network Undertaking against Hepatitis C (CANUHC) Cohort contains demographic information and DAA treatment information prospectively collected at 10 Canadian sites. Information on country of or  ...[more]

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