MiR-762 regulates the proliferation and differentiation of retinal progenitor cells by targeting NPDC1.

ABSTRACT: Retinal degenerations, which lead to irreversible decline in visual function, are still no effective recovery treatments. Currently, retinal progenitor cell (RPC) transplantation therapy is expected to provide a new approach to treat these diseases; however, the limited proliferation capacity and differentiation potential toward specific retinal neurons of RPCs hinder their potential clinical applications. microRNAs have been reported to serve as important regulators in the cell fate determination of stem/progenitor cells. In this study, our data demonstrated that miR-762 inhibited NPDC1 expression to positively regulate RPC proliferation and suppress RPC neuronal differentiation. Furthermore, the knockdown of miR-762 upregulated NPDC1 expression in RPCs, leading to the inhibition of RPC p

SUBMITTER: Gao H 

PROVIDER: S-EPMC7469545 | biostudies-literature | 2020 Jul

REPOSITORIES: biostudies-literature