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Baseline estrogen levels in postmenopausal women participating in the MAP.3 breast cancer chemoprevention trial.


ABSTRACT: OBJECTIVE:The aim of the study was to quantify baseline estradiol (E2) and estrone (E1) concentrations according to selected patient characteristics in a substudy nested within the MAP.3 chemoprevention trial. METHODS:E2 and E1 levels were measured in 4,068 postmenopausal women using liquid chromatography-tandem mass spectrometry. Distributions were described by age, years since menopause, race, body mass index (BMI), smoking status, and use and duration of hormone therapy using the Kruskal-Wallis test. Multivariable linear regression was also used to identify characteristics associated with estrogen levels. RESULTS:After truncation at the 97.5th percentile, the mean (SD)/median (IQR) values for E2 and E1 were 5.41 (4.67)/4.0 (2.4-6.7) pg/mL and 24.7 (14.1)/21 (15-31) pg/mL, respectively. E2 and E1 were strongly correlated (Pearson correlation [r] = 0.8, P?

SUBMITTER: Richardson H 

PROVIDER: S-EPMC7469568 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature

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Baseline estrogen levels in postmenopausal women participating in the MAP.3 breast cancer chemoprevention trial.

Richardson Harriet H   Ho Vikki V   Pasquet Romain R   Singh Ravinder J RJ   Goetz Matthew P MP   Tu Dongsheng D   Goss Paul E PE   Ingle James N JN  

Menopause (New York, N.Y.) 20200601 6


<h4>Objective</h4>The aim of the study was to quantify baseline estradiol (E2) and estrone (E1) concentrations according to selected patient characteristics in a substudy nested within the MAP.3 chemoprevention trial.<h4>Methods</h4>E2 and E1 levels were measured in 4,068 postmenopausal women using liquid chromatography-tandem mass spectrometry. Distributions were described by age, years since menopause, race, body mass index (BMI), smoking status, and use and duration of hormone therapy using t  ...[more]

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