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Unbiased translation proteomics upon cell stress.


ABSTRACT: The mammalian target of rapamycin and the integrated stress response are central cellular hubs regulating translation upon stress. The precise proteins and pathway specificity of translation targets of these pathways remained largely unclear. We recently described a new method for quantitative translation proteomics and found that both pathways control translation of the same sets of proteins.

SUBMITTER: Klann K 

PROVIDER: S-EPMC7469668 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature

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Unbiased translation proteomics upon cell stress.

Klann Kevin K   Münch Christian C  

Molecular & cellular oncology 20200518 4


The mammalian target of rapamycin and the integrated stress response are central cellular hubs regulating translation upon stress. The precise proteins and pathway specificity of translation targets of these pathways remained largely unclear. We recently described a new method for quantitative translation proteomics and found that both pathways control translation of the same sets of proteins. ...[more]

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