Hubs of long-distance co-alteration characterize brain pathology.
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ABSTRACT:
SUBMITTER: Cauda F
PROVIDER: S-EPMC7469792 | biostudies-literature | 2020 Jun
REPOSITORIES: biostudies-literature
Publications
Hubs of long-distance co-alteration characterize brain pathology.
Cauda Franco F Mancuso Lorenzo L Nani Andrea A Ficco Linda L Premi Enrico E Manuello Jordi J Liloia Donato D Gelmini Gabriele G Duca Sergio S Costa Tommaso T
Human brain mapping 20200620 14
It is becoming clearer that the impact of brain diseases is more convincingly represented in terms of co-alterations rather than in terms of localization of alterations. In this context, areas characterized by a long mean distance of co-alteration may be considered as hubs with a crucial role in the pathology. We calculated meta-analytic transdiagnostic networks of co-alteration for the gray matter decreases and increases, and we evaluated the mean Euclidean, fiber-length, and topological distan ...[more]
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