FOXO1 inactivation induces cisplatin resistance in bladder cancer.
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ABSTRACT:
SUBMITTER: Ide H
PROVIDER: S-EPMC7469822 | biostudies-literature | 2020 Sep
REPOSITORIES: biostudies-literature
Publications
FOXO1 inactivation induces cisplatin resistance in bladder cancer.
Ide Hiroki H Goto Takuro T Teramoto Yuki Y Mizushima Taichi T Jiang Guiyang G Nagata Yujiro Y Inoue Satoshi S Baras Alexander S AS Kashiwagi Eiji E Miyamoto Hiroshi H
Cancer science 20200717 9
We found that FOXO1-shRNA sublines or FOXO1-positive cells co-treated with a FOXO1 inhibitor were significantly more resistant to cisplatin treatment at pharmacological concentrations, compared with respective control sublines or those with mock treatment. Western blot demonstrated considerable increases in the expression levels of a phosphorylated inactive form of FOXO1 (p-FOXO1) in cisplatin-resistant sublines established by long-term culture with low/increasing doses of cisplatin, compared wi ...[more]
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