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Biology and therapeutic potential of mesenchymal stem cell-derived exosomes.

ABSTRACT: Mesenchymal stem cells (MSC) are multipotent stromal cells with the potential to differentiate into several cell types. MSC-based therapy has emerged as a promising strategy for various diseases. Accumulating evidence suggests that the paracrine effects of MSC are partially exerted by the secretion of soluble factors, in particular exosomes. MSC-derived exosomes are involved in intercellular communication through transfer of proteins, RNA, DNA and bioactive lipids, which might constitute a novel intercellular communication mode. This review illustrates the current knowledge on the composition and biological functions as well as the therapeutic potential of MSC-derived exosomes in cancer, with a focus on clinical translation opportunities.

SUBMITTER: Xunian Z

PROVIDER: S-EPMC7469857 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature

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Biology and therapeutic potential of mesenchymal stem cell-derived exosomes.

Xunian Zhou Z Kalluri Raghu R

Cancer science 20200728 9

Mesenchymal stem cells (MSC) are multipotent stromal cells with the potential to differentiate into several cell types. MSC-based therapy has emerged as a promising strategy for various diseases. Accumulating evidence suggests that the paracrine effects of MSC are partially exerted by the secretion of soluble factors, in particular exosomes. MSC-derived exosomes are involved in intercellular communication through transfer of proteins, RNA, DNA and bioactive lipids, which might constitute a novel ...[more]

PMID: 32639675

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