Dataset Information

How Tasks Change Whole-Brain Functional Organization to Reveal Brain-Phenotype Relationships.

ABSTRACT: Functional connectivity (FC) calculated from task fMRI data better reveals brain-phenotype relationships than rest-based FC, but how tasks have this effect is unknown. In over 700 individuals performing seven tasks, we use psychophysiological interaction (PPI) and predictive modeling analyses to demonstrate that task-induced changes in FC successfully predict phenotype, and these changes are not simply driven by task activation. Activation, however, is useful for prediction only if the in-scanner task is related to the predicted phenotype. To further characterize these predictive FC changes, we develop and apply an inter-subject PPI analysis. We find that moderate, but not high, task-induced consistency of the blood-oxygen-level-dependent (BOLD) signal across individuals is useful for prediction. Together, these findings demonstrate that in-scanner tasks have distributed, phenotypically relevant effects on brain functional organization, and they offer a framework to leverage both task activation and FC to reveal the neural bases of complex human traits, symptoms, and behaviors.

SUBMITTER: Greene AS

PROVIDER: S-EPMC7469925 | biostudies-literature | 2020 Aug

REPOSITORIES: biostudies-literature

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How Tasks Change Whole-Brain Functional Organization to Reveal Brain-Phenotype Relationships.

Greene Abigail S AS Gao Siyuan S Noble Stephanie S Scheinost Dustin D Constable R Todd RT

Cell reports 20200801 8

Functional connectivity (FC) calculated from task fMRI data better reveals brain-phenotype relationships than rest-based FC, but how tasks have this effect is unknown. In over 700 individuals performing seven tasks, we use psychophysiological interaction (PPI) and predictive modeling analyses to demonstrate that task-induced changes in FC successfully predict phenotype, and these changes are not simply driven by task activation. Activation, however, is useful for prediction only if the in-scanne ...[more]

PMID: 32846124

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Dataset Information

How Tasks Change Whole-Brain Functional Organization to Reveal Brain-Phenotype Relationships.

Publications

How Tasks Change Whole-Brain Functional Organization to Reveal Brain-Phenotype Relationships.

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