Ontology highlight
ABSTRACT:
SUBMITTER: Thunders M
PROVIDER: S-EPMC7470178 | biostudies-literature | 2020 Sep
REPOSITORIES: biostudies-literature
Thunders Michelle M Delahunt Brett B
Journal of clinical pathology 20200901 12
Transmembrane serine protease 2 is encoded by the <i>TMPRSS2</i> gene. The gene is widely conserved and has two isoforms, both being autocatalytically activated from the inactive zymogen form. A fusion gene between the <i>TMPRSS2</i> gene and <i>ERG</i> (erythroblast-specific-related gene), an oncogenic transcription factor, is the most common chromosomal aberration detected in prostate cancer, responsible for driving carcinogenesis. The other key role of <i>TMPRSS2</i> is in priming the viral s ...[more]